I have been researching and trying to resolve this error for the past couple of weeks (off and on). It only happens on Windows 2000 machines, and seems to have started sometime in Aug-2007. Other items, it only happens if the machine is left on over night, and rebooting will fix the problem.
The “Details: The system cannot find the file specified” would be helpful if it listed a file it was having problems with.
TIDBIT: This post was the first using the Adobe Air Application “Bee” and it’s ability to work with my Flickr Photos and this blog at the same time.